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2018, Planta medica
Three diynes, octadec-17-ene-9,11-diynoate ethyl (1: ), 8-hydroxy-octadeca-13,17-diene-9,11-diynoate ethyl (2: ), and 8-hydroxy-octadec-13-ene-9,11-diynoate ethyl (3: ), were isolated from Ongokea gore seed oil. The structure assignment of these three compounds was based according to chemical and spectroscopic data. They were screened against Plasmodium falciparum, the parasite that causes malaria. In vitro micro-test (Mark III, supported by the World Health Organization) was developed to assess the response of P. falciparum to the isolated three compounds, and statistical analysis were performed for determination of the concentration that inhibits 50% of the parasite maturation (IC50). Two of the three diynes (2: and 3: ) showed a very effective in vitro antimalarial activity with an IC50 of 4.5 and 1.7 µM, respectively. Compound 3: exhibited better activity than quinine (IC50 1.9 µM), the drug reference, while compound 1: had no antimalarial activity (IC50 > 125 µM). In the MTT...
2012 •
Planta medica
Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical Study2017 •
Natural products are generally ingested as part of traditional herbal decoctions or in the current diet. However, in natural product research, the bioavailability of secondary metabolites is often poorly investigated. In this work, a systematic study was carried out in order to highlight the physicochemical parameters that mainly influence the passive intestinal absorption of natural products. For this, a representative set of natural products including alkaloids, coumarins, flavonoid aglycones and glycosides, and carboxylic acids was selected and their physicochemical properties were predicted using relevant Volsurf+ descriptors. The chemical space obtained with this unbiased method was then correlated with experimental passive intestinal permeability data, which highlighted the main influence of lipophilicity, global hydrophilicity, size, and the ionisation state on passive intestinal absorption of natural products. Since the pH range encountered in the intestine is wide, the infl...
Endophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology. Metabolomic tools were successfully employed to compare the metabolite fingerprints of solid and liquid culture extracts of endophyte Curvularia sp. isolated from the leaves of Terminalia laxiflora. Natural product databases were used to dereplicate metabolites in order to determine known compounds and the presence of new natural products. Multivariate analysis highlighted the putative metabolites responsible for the bioactivity of the fungal extract and its fractions on NF-κB and the myelogenous leukemia cell line K562. Metabolomic tools and dereplication studies using high-resolution electrospray ionization mass spectrometry directed the fractionation and isolation of the bioactive components from the fungal extracts. This resulted in the isolation of N-acetylphenylalanine (1) and two linear peptide congeners of 1: dipeptide N-acetylphenylalanyl-L-phenylalanine (2) and tripepti...
emergent Life Sciences Research
A review on the Phytochemistry and Pharmacological properties of Picralima nitida Durand and H. (Apocynaceae family): A potential antiCovid-19 medicinal plant speciesPlanta Medica International Open
(+)-Usnic Acid Isolated from the Lichen Cladonia substellata Impairs Myocardial ContractilityThe scientific interest in (+)-usnic acid has grown because of its antitumor, cytotoxic, and antimicrobial activities as well as weight loss. However, overuse of usnic acid has been related with severe hepatotoxicity, making its use questionable. In this study, we decided to expand the knowledge of usnic acid biological activities by characterizing its effects on the mammalian myocardium as a potential pharmacological target. Usnic acid was isolated from samples of Cladonia substellata and submitted to chemical characterization. Molecular inclusion complexes of usnic acid with hydroxypropyl β-cyclodextrin were prepared to improve its water solubility. The effects of usnic acid on the atrial contractility and Ca2+ influx were carried out in the left atrium of guinea pigs and the effect of usnic acid on the L-type Ca2+ current was performed in rat ventricular cardiomyocytes enzymatically isolated. To evaluate the membrane integrity of cells subjected to usnic acid, we used histologica...
Planta Medica
Three New Abietane-Type Diterpenoids from Plectranthus africanus and Their Antibacterial ActivitiesThree new abietane-type diterpenoids, plectranthroyleanones A – C (1 – 3), together with five known compounds (4 – 8) were isolated from the methanol extract of the whole plant of Plectranthus africanus using column chromatography techniques. The structures of the new compounds were elucidated using a combination of 1D and 2D NMR and HRESIMS analyses. Compound 1 exhibited weak activities with minimal inhibitory concentration values of 75 µg/mL against gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, and 150 µg/mL against two gram-negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumoniae, respectively, while 2 and 3 had moderate antibacterial activity against K. pneumoniae with a minimal inhibitory concentration value of 37.5 µg/mL.
2019 •
Resumen Context: Garcinia kola seeds are widely used in Congolese traditional medicine to treat uncomplicated malaria. While the ethanolic extract of these seeds (GK) is reputed for oral antimalarial activity, some of its constituents have shown poor water solubility, which might compromise further phytopharmaceutical developments. Aims: To develop a self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of GK, since SNEDDS are promising vehicles for enhancing drug product solubility. Methods: GK was loaded into liquid SNEDDS (solution and suspension) and solid SNEDDS (S-SNEDDS), and the resultant formulations were characterized using dynamic light scattering and electron microscopy. The antimalarial activity of SNEDDS (200 mg/kg × 4 days, oral) was evaluated in Plasmodium berghei-infected mice using a conventional fourday suppressive test. Results: The characterization of SNEDDS formulations revealed the presence of nanosized structures of spherical morphology and neg...
Journal of Ethnopharmacology
In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine2010 •
2009 •
The objective of this study was to validate scientifically the antimalarial effectiveness and safety of A. senegalensis. Ethanolic crude extracts of Annona senegalensis growing in Democratic Republic of the Congo were evaluated for the inhibitory effects on two malaria parasites strains (P. falciparum FcM29 & P. yoelii subsp nigeriensis) and cytotoxicity towards leukaemia P-388 cell lines. Results indicate that, the antiplasmodial activities of tested plant extracts are moderate in vitro and weak in vivo. While the leaves crude extract displayed toxic effect towards P-388 cells. So, the wide use of this medicinal plant in Congolese Folk Medicine as antimalarial herbal could constitutes a great risk of population poisoning. of the Congo. INTRODUCTION Malaria is an infectious disease caused by a protozoan of the phylum: Apicomplexa, class: Sporozoa, subclass: Coccidia, suborder: Haemosporina, family: Plasmodidae, genus Plasmodium and transmitted by the female mosquito of the genus Ano...
Planta Medica
Anti-inflammatory and Membrane-stabilizing Stigmastane Steroids from Alchornea floribunda Leaves2010 •
American Journal of Tropical Medicine and Hygiene
Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo2009 •
2009 •
Planta Medica
Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone2016 •
Planta Medica International Open
Constituents of Acacia nilotica (L.) Delile with Novel Kinase Inhibitory ActivityInternational Blood Research & Reviews
Antisickling Activity and Membrane Stabilizing Effect of Anthocyanins Extracts from Adansonia digitata L. Barks on Sickle Blood Cells2004 •
Planta Medica
Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi2011 •
Journal of Ethnopharmacology
Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo1999 •
Planta Medica
Phytochemical investigation and microscopic analysis of aerial parts of Otostegia persica2010 •
Arzneimittelforschung
Synthesis and Biological Activities of Some 1,3-Benzoxazol-2(3H)-One Derivatives as Anti-Quorum Sensing Agents2012 •
2011 •
2008 •
Planta Medica International Open
Nanoemulsion Improves Antinociceptive Activity of HP1, a Benzopyran from Hypericum polyanthemum2011 •
2017 •
2011 •
Planta Medica
Antibacterial activity of some Serbian aromatic plants in relation to selected phytopathogenic bacteria2007 •
Acta Poloniae Pharmaceutica
Development, validation and application of the HPLC method for determination of mianserin in human serum2007 •
2021 •
Planta Medica
Screening of Tanzanian Medicinal Plants against Plasmodium falciparum and Human Immunodeficiency Virus2010 •
2012 •
2016 •
Planta Medica
Cytotoxic Arylnaphthalide Lignan Glycosides from the Aerial Parts of Phyllanthus taxodiifolius2006 •
Planta medica
Pharmacokinetics of hERG Channel Blocking Voacangine in Wistar Rats Applying a Validated LC-ESI-MS/MS Method2016 •
International Journal of Biological and Chemical Sciences
Antimalarial efficacy and toxicity evaluation of 80% ethanol extracts from the stem bark of Enantia olivacea, Garcinia punctata and Massularia acuminataPlanta medica
Isolation of Bioactive Rotenoids and Isoflavonoids from the Fruits of Millettia caerulea2016 •
2017 •